Are specific viral antibody responses associated with the development of MOGAD compared to RRMS?
Patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and relapsing-remitting multiple sclerosis (RRMS)
MOGAD patients compared to RRMS patients
Virus antibody responses (SARS-CoV-2, HHV6, CMV, JCV, EBV)surrogate
EBV serology differs between MOGAD and RRMS, suggesting distinct viral etiologies for these demyelinating diseases.
Our findings suggest that development of MOGAD is neither associated with SARS-CoV-2, HHV6, CMV nor JCV alone. Furthermore, results presented indicate that EBV serology is different in MOGAD patients compared to RRMS, confirming a role of EBV in the development of MS and suggesting that the etiology of MOGAD is different from MS.
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JLgnh Frederiksen
D Žiogienė
R Slibinskas
Multiple Sclerosis and Related Disorders
University of Southern Denmark
Glostrup Hospital
Vilnius University
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Frederiksen et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75a1cc6e9836116a1fa5f — DOI: https://doi.org/10.1016/j.msard.2026.107014