March 3, 2026

Nasal Biomarkers of Acute Illness Severity and Predictors of Recurrent Wheeze in Infants Infected With Respiratory Syncytial Virus

Key Points

Acute disease severity is linked to nasal gene expression and microbiome changes during RSV infection.
Nasal biomarkers predict recurrent wheeze, with 12-month follow-up confirming the association for infants.
Observational analysis focused on infants with primary RSV infection to explore nasal microbiome and gene profiles.
Findings highlight the potential for early identification of wheezing risks in infants, warranting further research.

Abstract

We prospectively followed infants with primary RSV infection and identified associations between nasal gene expression, microbiome composition/function and acute disease severity and recurrent wheeze. Host transcriptional profiles during infection were predictive of recurrent wheeze within the following year.

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Cite This Study

Caserta et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75a57c6e9836116a200cd https://doi.org/https://doi.org/10.1093/infdis/jiag049

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