March 3, 2026Open Access

FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma

Key Points

FOXM1 influences DNA methylation, enhancing TACC3 alternative splicing in hepatocellular carcinoma.
Key evidence shows that inhibiting TACC3 can synergistically disrupt mitotic fidelity and transcriptional regulation.
Analysis focused on the interactions between TACC3 and KAT2A, revealing crucial regulatory pathways in cancer.
This highlights a potential therapeutic avenue with reduced toxicity, signaling a need for further exploration in clinical applications.

Abstract

We uncovered TACC3-KAT2A as an emerging regulatory axis caused by alternative splicing in HCC and propose FOXM1-driven TACC3 inhibition to synergistically disrupt mitotic fidelity and transcriptional regulation, potentially offering new therapeutic avenues for HCC with reduced toxicity to the normal liver.

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Discussion

Authors

Li Na Zhao

University of Copenhagen

Jesper B. Andersen

University of Copenhagen

Journals

Clinical and Molecular Hepatology

Actions

Institutions

University of Copenhagen

References and Citations

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Building similarity graph...

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FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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