March 3, 2026Open Access

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model

Key Points

Tumor progression is enhanced by APOBEC3A and APOBEC3H Haplotype I compared to APOBEC3B.
The study highlights significant differences in tumor behavior based on genetic variants.
Three APOBEC3 variants were assessed using a breast cancer xenograft model in mice.
These findings suggest that specific APOBEC3 haplotypes may inform treatment strategies for breast cancer.

Abstract

The results indicate that in a breast cancer xenograft model, APOBEC3A and APOBEC3H Haplotype I are more likely to contribute to enhanced tumor progression than APOBEC3B.

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