Tumor-associated macrophages in head and neck carcinoma: clinicopathological correlations and implications for immunotherapy

Key Points

• Tumor-associated macrophages correlate with the immune response in head and neck carcinoma, influencing treatment outcomes.
• Key evidence shows that increased tumor-associated macrophages relate to poorer survival rates in clinical settings.
• Observational analysis shows how clinicopathological features align with macrophage presence in tumor tissues, and their functional roles.
• These findings highlight the potential for targeting macrophages to enhance immunotherapy effectiveness in head and neck carcinoma.