Effects of PFOA and emerging alternatives at environmental concentrations on murine- and human-derived microglia: A comparative study

Key Points

• Microglia from both murine and human sources show altered function when exposed to PFOA.
• PFOA exposure resulted in significant neuroinflammatory responses measured in both models.
• Assessment of microglial response utilized both murine- and human-derived cell cultures to improve translational understanding.
• Impacts highlight the need for evaluating environmental neurotoxicants in diverse biological setups.