Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

Key Points

• Lactate consumption patterns were identified in colorectal cancer, revealing a diverse metabolic landscape.
• The study highlights distinct Warburg niches, which may indicate varying tumor metabolism among different cancer types.
• Spatial flux balance analysis (FBA) was used to assess metabolic variations in renal tumors and colorectal cancer.
• Understanding these metabolic differences could enhance targeted therapies and improve patient outcomes.