Glymphatic dysfunction and its association with clinical symptom severity in narcolepsy type 1: a case–control DTI-ALPS study

Key Points

• Glymphatic dysfunction correlates with increased clinical symptom severity in narcolepsy type 1.
• Diffusion tensor imaging measures revealed significant differences between cases and controls.
• Case-control study design provides a clear comparison of symptom severity and glymphatic functionality.
• Findings indicate potential pathways for future therapeutic interventions in narcolepsy type 1.