Dimensionality reduction of quantitative EEG and clinical profiles uncover associations with monogenic neurodevelopmental phenotypes in SNAREopathies
Key Points
Distinct clinical severity dimensions correspond with normative quantitative EEG metrics and track disorder progression effectively.
Association features show promise in identifying therapeutic response based on quantitative EEG deviations illustrating clinical profiles.
Analysis of normative metrics reveals how functional aspects of EEG relate to the severity of neurodevelopmental phenotypes within SNAREopathies.
Support for efficacy in monitoring therapeutic outcomes highlights the potential for improved clinical management of SNAREopathies.
Abstract
Normative qEEG deviance metrics correspond to distinct clinical severity dimensions in SNAREopathies, making them promising for tracking disorder progression and therapeutic response.
Dimensionality reduction of quantitative EEG and clinical profiles uncover associations with monogenic neurodevelopmental phenotypes in SNAREopathies | Synapse