Does tocilizumab combined with 30 mg/(kg·day) methylprednisolone improve neurological outcomes compared to 20 mg/(kg·day) in children with acute necrotizing encephalopathy?
Children with acute necrotizing encephalopathy (ANE)
Tocilizumab combined with 30 mg/(kg·day) methylprednisolone
Tocilizumab combined with 20 mg/(kg·day) methylprednisolone
Neurological outcomeshard clinical
A higher initial dose of methylprednisolone (30 mg/kg/day) combined with tocilizumab may offer neuroprotective advantages over a 20 mg/kg/day dose in pediatric acute necrotizing encephalopathy.
In pediatric ANE, tocilizumab combined with 30 mg/(kg·day) MP was associated with improved neurological outcomes compared with 20 mg/(kg·day), with comparable mortality and safety profiles. These findings suggest that a higher initial MP dose may offer neuroprotective advantages, warranting further validation in prospective, multicenter studies.
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Fei Li
Beijing Children’s Hospital
Kechun Li
Chaonan Fan
Beijing Children’s Hospital
SHILAP Revista de lepidopterología
Pediatric Investigation
Beijing Children’s Hospital
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Li et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b53c6e9836116a2276d — DOI: https://doi.org/10.1002/ped4.70039