circSH3GL3 inhibits glioma progression and invasion via regulating the PI3K/AKT and Wnt/β-catenin signaling pathways by competitively binding with miR-21-5p | Synapse
March 3, 2026
circSH3GL3 inhibits glioma progression and invasion via regulating the PI3K/AKT and Wnt/β-catenin signaling pathways by competitively binding with miR-21-5p
Key Points
Inhibition of glioma progression is linked to the regulation of the PI3K/AKT and Wnt/β-catenin pathways.
Key evidence shows that higher circSH3GL3 levels correspond to significantly reduced invasion rates in glioma cells.
This analysis utilizes competitive binding assays to assess the interaction between circSH3GL3 and miR-21-5p.
The findings suggest that targeting circSH3GL3 may offer new strategies for glioma treatment.