This study reveals the widespread circulation of high-risk, multidrug-resistant UPEC clones in community-acquired UTIs, particularly those belonging to the globally disseminated ST131 lineage. The frequent coexistence of resistance determinants, virulence factors, and IncF plasmids highlights the adaptive success of these strains and their potential for sustained dissemination. These findings emphasize the need for continuous genomic surveillance, rational antimicrobial use, and region-specific treatment guidelines to mitigate the impact of MDR UPEC in the community.
Tano et al. (Tue,) studied this question.