Long non-coding RNAs as orchestrators of dosage compensation

Key Points

• Long non-coding RNAs play a critical role in dosage compensation mechanisms, enhancing gene regulation across diverse organisms.
• Key evidence shows that alterations in long non-coding RNAs can impact chromatin states and ultimately influence expression levels of genes.
• Observational analysis highlights genetic regulation patterns involving long non-coding RNAs across various species at multiple developmental stages.
• Further exploration into long non-coding RNAs is needed to understand their full implications for dosage compensation in broader biological contexts.