Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration

Key Points

• Cedrol promotes hair regeneration through modulation of macrophage polarization and immune response.
• Specifically, the treatment increased M2 macrophage polarization while reducing M1 polarization, showing a 40% increase in regeneration efficacy.
• Assessment involved in vitro macrophage polarization assays and hair follicle organ culture models to evaluate growth effects.
• Indirect evidence signals potential therapeutic applications for hair regeneration, yet broader studies are needed to confirm efficacy in humans.