Intestinal macrophages modulate synucleinopathy along the gut–brain axis

Key Points

• Synucleinopathy is significantly modulated by intestinal macrophages in relation to the gut-brain axis.
• Key evidence suggests inflammation levels correlate with synucleinopathy progression.
• Assessment using existing animal models shows how gut-brain signaling pathways are involved.
• These findings indicate potential new strategies for treating neurodegenerative diseases linked to gut health.