Heme-glycolysis interplay in oral squamous cell carcinoma: insights into SLC48A1 and GLUT1 expression across histological grades

Key Points

• Oral squamous cell carcinoma shows distinct variations in SLC48A1 and GLUT1 expression across different histological grades.
• Increased SLC48A1 and GLUT1 levels correlate with higher tumor aggressiveness in this cancer type.
• Observational analysis across various grades highlights the interplay between heme metabolism and glycolysis in oral squamous cell carcinoma.
• Understanding these expressions may enable better metabolic-targeted therapies in oral squamous cell carcinoma.