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A Case Report of End-of-Dosage Failure With Buprenorphine Patch | Synapse
March 3, 2026
A Case Report of End-of-Dosage Failure With Buprenorphine Patch
SW
Samiddhi D. Weerasiri
Mayo Clinic
LS
Leslie R. Siegel
Mayo Clinic
RM
Regina M. Mackey
Key Points
End-of-dosage failure was observed with the buprenorphine patch, negatively affecting pain relief.
Key evidence indicates significant pain resurgence after patch effectiveness diminished over time.
Reporting a case of dosage failure, the evaluation involved clinical assessments over several weeks.
The report highlights the need for careful monitoring of patients on transdermal opioid therapy.
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Weerasiri et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75bdac6e9836116a23ea2
https://doi.org/https://doi.org/10.1016/j.jpainsymman.2026.01.018