Prognostic gene screening and experimental validation in renal clear cell carcinoma based on spatial transcriptomics and single-cell sequencing

Key Points

• The prognostic value of the identified gene screening improves risk stratification for renal clear cell carcinoma patients.
• ATP1A1 shows potential as a therapeutic target, influencing angiogenesis and immune modulation pathways.
• This study employs spatial transcriptomics and single-cell sequencing to investigate ccRCC gene signatures.
• Findings support the development of personalized treatment strategies, highlighting significant clinical relevance.