HLA‐DQA1*01:181N , a Novel HLA‐DQA1 Allele Identified by Next‐Generation Sequencing

Key Points

• HLA-DQA1*01:181N is characterized by a single nucleotide substitution in exon 2, specifically codon 69.
• The nucleotide change involves TTG being replaced by TAG, which could alter protein function.
• Next-generation sequencing was utilized to effectively identify this novel allele associated with HLA-DQA1.
• Findings highlight the need for further research to understand the implications of this allele in immune response.