Multidimensional MRI is only one piece of the puzzle in the diagnosis of stroke-like episodes in MELAS

Key Points

• Stroke-like episodes often occur in MELAS patients, with multidimensional MRI serving as a critical diagnostic tool.
• MRI findings highlight specific stroke characteristics, aiding in diagnosis but not capturing the full clinical picture.
• Observational analysis based on clinical evaluations and imaging studies across numerous institutions reveals the complexity of diagnosing these episodes.
• The findings underscore the need for a combination of diagnostics and clinical assessments to improve stroke-like episode identification in MELAS.