Investigation of Acoramidis-based ionic liquids as potential stabilizers of transthyretin using DFT calculations, molecular docking, and ADMET studies | Synapse
March 3, 2026Open Access
Investigation of Acoramidis-based ionic liquids as potential stabilizers of transthyretin using DFT calculations, molecular docking, and ADMET studies
Key Points
Acoramidis-based ionic liquids stabilize transthyretin, potentially aiding treatment of amyloidosis.
Using molecular docking, the study found binding affinities suggesting effective stabilization mechanisms.
Assessment included density functional theory calculations and evaluations of drug-like properties through ADMET studies.
Findings highlight the therapeutic promise of acoramidis formulations for managing transthyretin-associated diseases.