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Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in C. elegans | Synapse
March 3, 2026
Open Access
Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in C. elegans
SG
Spencer S. Gang
University of California, San Diego
MS
Max W Strul
University of California, San Diego
DR
Desmond Richmond-Buccola
University of California, San Diego
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Key Points
Mitochondrial fragmentation is influenced by immune regulators PALS-25 and PALS-22, enhancing our understanding of mitochondrial dynamics.
In experiments, PALS-25 and PALS-22 localized to mitochondria, showing a direct relationship with mitochondrial fragmentation.
The method involved observing C. elegans and their mitochondrial behavior with respect to immune regulator activity.
Future research may indicate broader roles for these markers in mitochondrial function across different biological systems.
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Cite This Study
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Gang et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c68c6e9836116a25454
https://doi.org/https://doi.org/10.1016/j.isci.2026.114814