Urinary 8-hydroxy-2’-deoxyguanosine as an early predictive biomarker for glomerular filtration rate decline in patients with type 2 diabetes mellitus

Key Points

• Urinary 8-hydroxy-2’-deoxyguanosine levels correlate significantly with glomerular filtration rate decline, indicating potential as an early biomarker.
• In a cohort of patients with type 2 diabetes, elevated urinary 8-hydroxy-2’-deoxyguanosine levels were associated with faster GFR decline.
• Assessment used urinary analysis to measure 8-hydroxy-2’-deoxyguanosine, linking it to changes in kidney function over time.
• Findings highlight the need for early monitoring of urinary biomarkers to prevent kidney complications in type 2 diabetes.