KCNB1 mutation impairs neuronal differentiation by disrupting gene expression temporal regulation and neuron-specific pathways
Key Points
Neuronal differentiation is significantly impaired by low expression of KCNB1, showing a disruption in maturation.
The temporal pattern of gene expression, critical for neuronal development, is altered due to KCNB1 mutation.
Assessment of gene regulation indicates that neuron-specific pathways are disrupted in this context.
This study highlights potential targets for therapeutic intervention in neurodevelopmental disorders associated with KCNB1.
Abstract
Low expression of KCNB1 disrupts the temporal pattern of gene expression and related neuron-specific pathways during neuronal differentiation and impairs neuronal differentiation and maturity.