Bletilla striata polysaccharide alleviates Alzheimer's disease in Caenorhabditis elegans by modulating autophagy via the insulin/AMPK pathway

Key Points

• Bletilla striata polysaccharide alleviates symptoms of Alzheimer's disease in C. elegans, enhancing neuronal health and longevity.
• Researchers reported significant improvement in cognitive function metrics by 30% after treatment with the polysaccharide.
• Analysis using C. elegans models reveals modulation of autophagy via the insulin/AMPK pathway, critical for cell maintenance and survival.
• This finding highlights a potential direction for developing therapies targeting autophagy pathways, though further research is needed.