Cell death and immune escape in the tumor microenvironment: associated mechanisms, opportunities and challenges

Key Points

• Immune escape mechanisms allow tumors to evade detection, leading to increased cell death rates among targeted therapies.
• Key relevance shown by the interaction of 15 identified biomarkers impacting tumor growth and immune responses.
• Observational analysis of cancer cells exposed to immune cells reveals critical insights into survival strategies and adaptations.
• Challenges in translating these findings to clinical settings may limit the effectiveness of immunotherapy options.