Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays

Key Points

• Olfactory deposition mechanisms enhance drug delivery to the brain, improving bioavailability.
• Machine learning-guided optimization reveals significant insights into nasal spray formulation efficiency.
• Analysis of nasal spray efficacy indicates better outcomes in targeting the central nervous system.
• Understanding olfactory delivery may enable more effective treatment options for neurological conditions.