FNDC4 regulates M2 polarization of tumor-associated macrophages to affect colorectal cancer metastasis

Key Points

• M2 polarization of tumor-associated macrophages is regulated by FNDC4, impacting colorectal cancer metastasis.
• Key evidence includes a significant shift in macrophage phenotype associated with FNDC4 expression.
• Analysis indicates FNDC4's role in the immune environment of colorectal cancer, highlighting its potential as a therapeutic target.
• Results may enable strategies targeting FNDC4 in clinical settings for managing colorectal cancer metastasis.