CircHIPK3 regulates TGF-β1/smad3 signaling in communicating hydrocephalus after intraventricular hemorrhage by sponging miR-30a-3p via ACT1

Key Points

• TGF-β1 signaling is altered, contributing to hydrocephalus after hemorrhage, and is influenced by circHIPK3 in this process.
• A 30% increase in smad3 activation was noted, linking the non-coding RNA circHIPK3 with miR-30a-3p.
• Assessment using gene expression analysis revealed that circHIPK3 interacts with ACT1, modulating the signaling pathway and outcomes in hydrocephalus.
• These findings suggest targeting this pathway could form a basis for future novel treatments, but further investigation in human models is required.