The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis | Synapse
March 3, 2026Open Access
The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis
Key Points
Increased cytotoxicity of γδ T cells enhances the immune response against Mycobacterium tuberculosis.
BTN3A1 is identified as a key regulator in the activation and response of γδ T cells.
RNA-sequencing analysis elucidates the mechanisms behind the enhanced cytolytic activity.
Understanding these mechanisms may lead to improved therapeutic interventions for tuberculosis.
Abstract
Our findings demonstrated that Mtb-HAg enhances the cytolytic activity of γδ T cells and inhibits intracellular Mtb growth, with BTN3A1 playing a regulatory role in these processes.