Exploring the toxicological mechanisms of reduced fertility in dairy cows due to nonesterified fatty acids on the basis of network toxicology, transcriptomics and molecular docking

Key Points

• Reduced fertility is associated with nonesterified fatty acids, affecting dairy cows' reproductive health.
• Analysis revealed critical insights into transcriptomic responses triggered by fatty acids in dairy cows.
• Employing molecular docking, the study evaluates the interaction of fatty acids on reproductive signaling pathways.
• Understanding these mechanisms may enable strategies to mitigate fertility issues in dairy farming.