Common and distinct patterns of aberrant amygdala functional connectivity in major depressive disorder and bipolar disorder: A voxel-wise comparative meta-analysis | Synapse
March 3, 2026
Common and distinct patterns of aberrant amygdala functional connectivity in major depressive disorder and bipolar disorder: A voxel-wise comparative meta-analysis
Key Points
Aberrant amygdala functional connectivity differentiates major depressive disorder and bipolar disorder, revealing unique patterns.
The comparative meta-analysis included studies that identified specific connectivity disruptions in both disorders.
Observational analysis across multiple datasets shows distinctive connectivity alterations in the amygdala for each mood disorder.
Understanding these neurobiological differences may enable better diagnosis and treatment strategies for mood disorders.