A Validated LC–MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis | Synapse
March 3, 2026
A Validated LC–MS/MS Method for Unbound Rifapentine Quantitation Reveals Nonlinear Plasma Protein Binding and Comparable Free Fractions Between Adults and Children with Tuberculosis
Key Points
Nonlinear plasma protein binding of rifapentine impacts the drug's efficacy and safety profile.
Free fractions of rifapentine were similar between adults and children, indicating consistent therapeutic effects.
Assessment involved a validated LC–MS/MS method for accurate quantitation of unbound rifapentine levels.
Understanding these binding characteristics can improve tuberculosis treatment strategies for diverse age groups.