SLC7A11-FUNDC1 axis drives Cr(VI)-Induced renal injury through mitophagy-ferroptosis crosstalk

Key Points

• Renal injury is driven by the SLC7A11-FUNDC1 axis, impacting mitochondrial health.
• Mitophagy and ferroptosis play key roles in chromium-induced cellular damage.
• Assessment using various biochemical methods highlights the relationship between these pathways in renal cells exposed to chromium.
• Understanding this interaction may enable the development of targeted therapies for chromium-induced kidney damage.