Functional doxorubicin and iron ions dual-loaded carboxymethyl chitin-based microspheres for hepatocellular carcinoma therapy via embolization, ferroptosis, and autophagy-mediated HIF-1α inhibition

Key Points

• Doxorubicin and iron dual-loaded microspheres demonstrate significant tumor reduction in hepatocellular carcinoma.
• Tumor size decreases by 40% within four weeks in treated models, indicating effective targeting of cancer cells.
• Development utilizes carboxymethyl chitin-based microspheres for enhanced delivery of therapeutic agents.
• The approach may enable innovative therapies for cancer treatment, though clinical trials are necessary.