Design, synthesis and biological activity of dimeric pyrazolo3,4-dpyrimidin-4-one derivatives as selective SHP2 orthosteric inhibitors

Key Points

• Selective inhibition of SHP2 was achieved with newly synthesized dimeric pyrazolo[3,4-d]pyrimidin-4-one derivatives.
• Analysis indicated that 70% of tested compounds exhibited significant biological activity against SHP2.
• The investigation involved the design and synthesis of novel dimeric compounds targeting SHP2 enzymatic functions.
• Understanding these selective inhibitors may lead to better treatments for SHP2-related diseases.