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Dose-dependent effects of vildagliptin (DPP-4 inhibitor) in a scopolamine-induced memory impairment model in rats | Synapse
March 3, 2026
Dose-dependent effects of vildagliptin (DPP-4 inhibitor) in a scopolamine-induced memory impairment model in rats
FM
Fazilet Sen Metin
EA
Elif Aksoz
Key Points
Memory impairment improved significantly with vildagliptin treatment, showing enhanced cognitive function.
The study indicates that higher doses lead to greater improvements in memory deficits, specifically in the scopolamine model.
Assessment using a scopolamine-induced memory impairment model highlights the role of vildagliptin as a DPP-4 inhibitor.
Therapeutic effects are observed in this rat model; further research is needed to establish human applicability.
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Metin et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75dd5c6e9836116a28198
https://doi.org/https://doi.org/10.1016/j.lfs.2026.124245
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