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Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling | Synapse
March 3, 2026
Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling
YH
Yingying Huang
BZ
Bo Zhang
RW
Richard Y. Wu
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Key Points
Intestinal injury is reduced by short-chain fructooligosaccharides, highlighting their protective potential.
Key evidence shows that treatment with fructooligosaccharides restores AKT/GSK-3β signaling in neonatal models.
Analysis of signaling pathways activation demonstrates the role of fructooligosaccharides in protecting gut health.
Results indicate significant implications for NEC management in neonatal intensive care settings.
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Huang et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75de2c6e9836116a282a0
https://doi.org/https://doi.org/10.1016/j.jpedsurg.2026.162963