Digital spatial profiling of α-PD-1 treated breast cancer bone metastases reveals region-specific signaling and enrichment of immune-suppressive markers | Synapse
March 3, 2026Open Access
Digital spatial profiling of α-PD-1 treated breast cancer bone metastases reveals region-specific signaling and enrichment of immune-suppressive markers
Key Points
Bone metastases exhibited unique signaling patterns distinct from primary tumors, indicating specialized tumor microenvironments.
Significant enrichment of immune-suppressive markers was found in specific regions of the breast cancer lesions.
Digital spatial profiling techniques were employed to map protein expression and cellular interactions in samples from breast cancer cases.
Findings may highlight targets for therapeutic strategies in managing breast cancer bone metastases, although further functional studies are needed.