Resistance of uropathogens to gepotidacin: A systematic review of in vitro antimicrobial susceptibility studies

Key Points

• Uropathogen resistance to gepotidacin varies significantly across studies, indicating a potential rise in treatment failures.
• Among 50 studies evaluated, resistance rates to gepotidacin reached up to 40%, highlighting a concerning trend.
• Systematic review of in vitro antimicrobial susceptibility studies demonstrated prevalence of resistance among diverse uropathogens.
• Concerns about rising resistance rates call for enhanced surveillance and possibly adjusted clinical treatment strategies.