From virtual screening to bench: A dual-validation framework for drug repurposing against PI3K

Key Points

• Drug repurposing strategies show promise in targeting the PI3K molecular pathway, yielding exciting opportunities.
• Virtual screening techniques were utilized to identify candidate medications, enhancing the drug discovery process.
• The developed dual-validation framework emphasizes the importance of both in vitro and in vivo testing for successful outcomes.
• This highlights the need for further exploration, as current findings require verification in broader clinical contexts.