BK channel activation has neuroprotective effects in a mouse model of NMOSD via reduction of neurotoxic astrocytes

Key Points

• Activation of BK channels leads to reduced neurotoxic astrocytes and neuroprotection.
• Significant reduction in the number of neurotoxic astrocytes was observed in response to BK channel activation.
• Analysis of a mouse model demonstrated the neuroprotective effects of BK channel activation in NMOSD.
• Findings suggest that BK channel activation may provide a new therapeutic target for NMOSD treatment.