Activating FcγRI inhibits RIG-I-mediated host antiviral innate immunity by FGR during PRRSV-ADE infection

Key Points

• Inhibition of RIG-I-mediated antiviral immunity occurs due to FcγRI activation, complicating host defense mechanisms.
• Key evidence shows a significant impairment of antiviral pathways, leading to enhanced susceptibility during PRRSV-ADE infection.
• Analysis focuses on the interaction between FcγRI and RIG-I in the context of viral infection, revealing critical immune interactions.
• This finding highlights the need for targeted therapies to counteract immune evasion strategies used by viruses.