Platelet-rich plasma enhances anti-apoptotic and paracrine effects of bone marrow mesenchymal stem cells through the PI3K/Akt pathway

Key Points

• Enhanced anti-apoptotic effects observed with platelet-rich plasma treatment in mesenchymal stem cells, boosting cellular survival.
• Key evidence reveals that platelet-rich plasma significantly increases the activation of the PI3K/Akt pathway, promoting cell health.
• Assessment using cellular assays demonstrated that paracrine signaling is improved in mesenchymal stem cells exposed to platelet-rich plasma.
• These findings suggest that platelet-rich plasma could play a vital role in regenerative therapies and enhancing tissue repair.