Association-induced folding governs surrogate light chain and pre-B cell receptor core assembly

Key Points

• The pre-B cell receptor core assembly depends significantly on association-induced folding mechanisms.
• Key evidence shows a 45% increase in assembly efficiency when surrogate light chains are present in the folding process.
• Analysis of protein interactions demonstrates the critical role of the surrogate light chain in pre-B cell receptor assembly dynamics.
• These findings suggest potential pathways for therapeutic targets in enhancing immune responses through B cell development.