March 3, 2026Open Access

High resolution genome-wide SNP array analyses on matched colorectal-based lung and brain metastases

Key Points

Brain metastases exhibited significantly more cn-loh regions compared to lung metastases, highlighting genetic variability.
Specific genes identified within these regions may alter signaling pathways like PI3K/AKT and affect cancer processes.
Investigations were based on high-resolution genome-wide SNP array analyses of matched metastases.
Increased awareness of these genetic characteristics offers potential for earlier diagnosis and better treatment options.

Abstract

Brain metastases of CRC showed more cn-LOH regions than lung metastases. Potentially affected genes within these regions could influence signaling pathways (e.g., PI3K/AKT signaling) as well as transcriptional processes. Perspectively, increased awareness of specific genetic characteristics can potentially increase the chance of early diagnosis of brain metastases, which could contribute to improved treatment options.

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Cite This Study

Brandt et al. (Fri,) studied this question.

synapsesocial.com/papers/69a75f24c6e9836116a2a4d7 https://doi.org/https://doi.org/10.1007/s00432-026-06427-7

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