Deep learning predicts and in vitro experiments validates the synergistic anti-liver cancer effect of vincristine and lenvatinib: Mechanism involving apoptosis induction via the TNF-α/Caspase-8 pathway

Key Points

• The combination of vincristine and lenvatinib induces significant apoptosis in liver cancer cells through the tnf-α/caspase-8 pathway.
• In vitro experiments demonstrate that this synergistic effect activates apoptosis at a higher rate than either drug alone.
• Deep learning algorithms were employed to predict the efficacy of the drug combination before experimental validation.
• These findings highlight the potential for using combined therapies to improve liver cancer treatment outcomes.