Radiation therapy combined with tyrosine kinase inhibitors in 826 patients with HER2-positive breast cancer brain metastases: a systematic review and network meta-analysis

Key Points

• This combined treatment approach shows significant improvement in managing brain metastases for HER2-positive breast cancer.
• Key evidence indicates a notable reduction in disease progression when utilizing this combination, enhancing patient outcomes.
• Systematic review and network meta-analysis highlight effectiveness across multiple studies, providing a robust overview of treatment efficacy.
• This strategy may enable better treatment protocols but requires further validation in larger cohorts to fully understand its impact.