Mapping single-cell datasets to large atlases is often hindered by server constraints and privacy concerns. We present CytoVerse, a framework that runs scRNA-seq Foundation Models (scFM) entirely in the browser. Three key contributions enable this: (1) deploying models via ONNX without server side compute; (2) using compressed indexing (IVFPQ) to search a more then 20 million cell reference from the client; and (3) a lightweight protocol for sharing embeddings across consortia without exposing raw data. CytoVerse thereby provides a scalable, privacy preserving framework for distributed single-cell analysis.
Currie et al. (Fri,) studied this question.