pH-responsive PLGA nanoparticles enable sustained curcumin release and preserve mitochondrial bioenergetics in cardiomyocytes

Key Points

• Sustained curcumin release enhances mitochondrial bioenergetics in cardiomyocytes, leading to improved cellular health.
• PLGA nanoparticles respond to pH changes, providing controlled drug delivery in varying environments, which is crucial for cardiac cells.
• The use of pH-responsive systems allows for targeted therapy in cardiovascular treatments, potentially reducing side effects.
• Such pH responsiveness may enable better therapeutic strategies for heart-related issues, highlighting the need for further exploration.